It has been over 14 years between the first publication of this Guidance Material and the current revision. In that time, significant changes have occurred to the National Airspace System (NAS) of the United States and to the Civilian Aviation ecosystem around the world. Significant advances have also been made in the field of Unmanned Aircraft Systems (UAS), many of those advances were noted in the first edition of this document and made possible thanks to the work of several RTCA Special Committees. UAS and UAS-related technologies have become an integral part of the global aviation landscape. Building on the legacy of the past 20 years and looking forward to the next 20 years, this document aims to provide guidance for industry, regulators, researchers, and other members of the aviation community. There will be a day in the future where remote pilots will safely, securely, and efficiently operate aircraft all over the world, and will share the skies with aircraft flown by on/off-board pilots.