Developed to assist management of refineries, petrochemical and chemical operations, natural gas liquids extraction plants, and other facilities covered by API Recommended Practice 750 or the Chemical Manufacturer Association's Process Safety Code in conducting process hazards analyses, as required by OSHA 1910.119, thereby improving industry's safety performance through cost-effective application of risk management and risk reduction alternatives. This publication provides a methodology for assessing and evaluating the hazards associated with location of process plant buildings that should be considered in process hazards analyses.